One Vitamin C STELLA 1 g effervescent tablet contains 1000 mg of Vitamin C (Ascorbic acid).
Pharmacology: Pharmacokinetics: Absorption: Ascorbic acid is readily absorbed after oral administration; however, absorption involves an active process and may be limited after very large doses. In one study in healthy individuals, only 50% of a single 1.5 g oral dose of ascorbic acid was absorbed. GI absorption of ascorbic acid may be reduced in patients with diarrhea or GI diseases.
Normal plasma concentrations of ascorbic acid are about 10-20 mcg/ml. Total body stores of ascorbic acid have been estimated to be about 1.5 g with about a 30-45 mg daily turnover. Clinical signs of scurvy usually become evident after 3-5 months of deficient ascorbic acid intake.
Distribution: Ascorbic acid is widely distributed in body tissues. About 25% of the ascorbic acid in plasma is bound to proteins.
Elimination: Ascorbic acid is reversibly oxidized to dehydroascorbic acid. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid which are excreted in the urine. When the body is saturated with ascorbic acid and blood concentrations exceed the threshold, unchanged ascorbic acid is excreted in the urine. Ascorbic acid is removed by hemodialysis.
Used as Health Supplement.
For oral administration. Dissolve one effervescent tablet in a glass of cold water. Preferably taken one hour after meals.
Adults: 1 tablet daily, or as directed by pharmacist or doctor.
Ascorbic acid may cause acidosis or haemolytic anaemia in certain individuals with a deficiency of glucose 6-phosphate dehydrogenase. Renal failure can occur with massive ascorbic acid overdosage.
Gastric lavage may be given if ingestion is recent otherwise general supportive measures should be employed as required.
Unsuitable for phenylketonurics.
Increased intake of ascorbic acid over a prolonged period may result in an increase in renal clearance and deficiency may result if it is withdrawn too rapidly.
Ascorbic acid in doses greater than 1g should not be administered during pregnancy as the effect of large doses on the foetus is not known.
No problems are anticipated with the administration of ascorbic acid tablets during lactation.
Nausea, vomiting and stomach cramps.
Flushing or redness of skin, headache, mild increase in urination with doses greater than 600 mg per day.
Large doses of ascorbic acid (greater than 1g per day) may cause diarrhea.
Concomitant administration of aluminium-containing antacids may increase urinary aluminium elimination. Concurrent administration of antacids and ascorbic acid is not recommended, especially in patients with renal insufficiency.
Concomitant administration of aspirin and ascorbic acid may interfere with absorption of ascorbic acid. Renal excretion of salicylate is not affected and does not lead to reduced anti-inflammatory effects of aspirin.
Concurrent administration of ascorbic acid with desferrioxamine enhances urinary iron excretion. Cases of cardiomyopathy and congestive heart failure have been reported in patients with idiopathic haemochromatosis and thalassaemias receiving desferrioxamine who were subsequently given ascorbic acid.
Ascorbic acid should be used with caution in these patients and cardiac function monitored.
Ascorbic acid may interfere with biochemical determinations of creatinine, uric acid and glucose in samples of blood and urine.
Store in a well-closed container, in a dry place.
Protect from light and moisture. Do not store above 30°C.
A11GA01 - ascorbic acid (vit C) ; Belongs to the class of ascorbic acid (vitamin C). Used as dietary supplements.
Vitamin C Stella 1 g
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